Young innovator paves way with African plants

YOUNG researcher makes groundbreaking discovery.

The discovery led to the identification of a novel compound with potential antiviral properties against respiratory infections.

Lesiba Thabo Lekgoathi (26), a PhD candidate at Sefako Makgatho Health Science University, told Daily Sun, he asked himself how he could make a difference through health science.

"That's when I got an opportunity to work on a project to evaluate the antiviral activity of selected medicinal plants used traditionally as home remedies to treat colds and flu," he said.

Lesiba's work focused on the Schinus Molle plant, also known as the pepperboom tree or mokwepere.

Under the supervision of Dr Vuyisile Samuel Thibane and Prof Sechene Stanley Gololo, he explored the biochemical potential of the plant and discovered a compound called Geranylgeranyl acetate, which demonstrated great potential to inhibit key enzymes of SARS-CoV-2.

"We knew we had uncovered something novel when we found that geranyl acetate had never been reported as a bioactive compound against respiratory infections. By disrupting key enzymes, this compound halts replication of the virus and prevents suppression of the immune system," said Lesiba.

However, Lesiba faced numerous challenges, including inaccessible infrastructure and financial struggles, but the emotional toll of losing loved ones during the Covid-19 pandemic was particularly difficult.

He remained driven by the potential impact of his work.

"The journey was not easy but knowing what could potentially come from the work I was doing, emotions soon became fuel and drove me to complete the work."

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With support from the National Research Foundation (NRF) and the Technology Transfer Office (TTO), Lesiba's work led to the successful provincial patenting of the compound and seed funding from the Technology Innovation Agency (TIA).

As he looks to the future, he hopes to partner with industry and government stakeholders to develop and commercialise the compound.

His ultimate goal is to equip people in less-fortunate areas with knowledge and skills to harness the health potential of medicinal plants.

"It's not only about science, it's about service, giving back and proving healing solutions can come from unexpected places," he said.